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This is the same concept used in constructing linkage maps or genetic mapping of diseases.
Howe (1963) argued that mapping of diseases tended to expose the "where" but not "why there" of the outbreak.
However, there currently exists no large-scale mapping of diseases to the cell types in which they are manifested.
The data set produced in this study represents the first large-scale mapping of diseases to the cell types in which they are manifested.
However, a lack of high-quality cell-type-specific gene expression data has previously limited the large-scale mapping of diseases to cell types.
Even when population size history is of secondary interest the incorporation of models of population size may improve the genetic mapping of diseases and estimation of genetic traits [ 4].
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Mapping of disease-related mutations onto the Nav1.7 structure model is highlighted by different colors.
These results reveal the substantial effects of mutational processes on LD at STRPs and provide important measures of the potential of STRPs for association mapping of disease genes.
Patterns of linkage disequilibrium (LD) reveal the action of evolutionary processes and provide crucial information for association mapping of disease genes.
Although, both populations do not show extensive LD, the easy reconstruction of large pedigrees in the Azorean population is a valuable resource for the fine mapping of disease genes.
This mapping of disease and making comparisons between oneself and others could be an emotional process, as one woman explained "it's upsetting because it's like looking in a mirror, looking at my mother and my sister, and my other sister, she's in a wheelchair now" (no.05 emphasis added).
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