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Mapping of disease risk variants to specific brain cell types in four brain diseases and seven non-brain diseases.
Taking advantage of this long-range LD, mapping of disease loci with GWAS becomes highly efficient, even with a relatively sparse number of tagSNPs8.
Patterns of linkage disequilibrium (LD) reveal the action of evolutionary processes and provide crucial information for association mapping of disease genes.
These results reveal the substantial effects of mutational processes on LD at STRPs and provide important measures of the potential of STRPs for association mapping of disease genes.
Specifically, his group is working in four areas, including genome sequencing and assembly, mapping of disease genes, the role of the major histocompatibility complex (MHC) in autoimmunity, and pharmacogenomics.
Although, both populations do not show extensive LD, the easy reconstruction of large pedigrees in the Azorean population is a valuable resource for the fine mapping of disease genes.
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Mapping of disease-related mutations onto the Nav1.7 structure model is highlighted by different colors.
This is the same concept used in constructing linkage maps or genetic mapping of diseases.
The ability to genotype common polymorphisms with SNP arrays has greatly enhanced the mapping of disease-associated loci [10].
Mapping of disease-related missense mutations onto the kinase domain structure revealed that the mutation sites could be classified into four different groups based on the location – dimer interface, interlobar helices, protein surface, or within other secondary structural elements.
This information might prove helpful in mapping of disease-causing mutations.
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