Sentence examples for mapping of causative from inspiring English sources

With the availability of genome sequences and high-density SNP genotyping microarrays the mapping of causative mutations for monogenic traits in domestic animal species has become a fairly straightforward procedure [3], [11].

Line-specific reaction norms for expression principal components indicate that genetic mapping of causative loci for diet-specific expression quantitative trait loci could be feasible.

More recently, Edwards and Gifford [ 16] developed a Bayesian network called MULTIPOOL to estimate the probability of linkage for each site and Leshchiner et al. [ 14] developed an HMM tailored to perform fine mapping of causative sites in mutagenesis experiments.

The basis for SNP-based mapping of causative mutations is presented in Figure 2. Recombinant females (* FRT2A/TM3, Sb or TM6, Tb F2 virgin recombinant females; " *?" representing the possibly mutant recombinant chromosome) were individually mated with tester males carrying TM3, Ser for phenotypic retesting, SNP mapping, and to make stocks of informative recombinants.

In the human genetics literature, the relative merits of SNPs and microsatellite for genome-wide scans of complex diseases have been compared [ 34- 38], but these studies have focused on the mapping of causative loci rather than the necessary initial step of map construction.

Landslide hazard zonation mapping requires determination of fuzzy membership function of causative factors.

At the time of the initial mapping of the causative locus we had samples from only four reliably diagnosed cases: Three affected littermates from the first family and one isolated case from the second family.

Quantitative trait loci associations with risk factors have been informative in Mendelian randomization studies as well as fine-mapping of causative variants.

This study highlights the need for reinforcement of case-based, laboratory confirmed surveillance of bacterial meningitis in Ethiopia to enable mapping of distribution of causative organisms across the country and determine the potential effects of existing vaccines.

The analysis of complex genetic traits, including mapping and identification of causative genes, has long been an enigma of genetic biology, whether in the animal sciences or in medical sciences.

We decided to investigate these SNPs in African-descended populations to test whether an effect is present, and whether the haplotype make-up in African-descended populations might facilitate further resolution and eventual fine-mapping of the causative genetic variation underlying HbF and FC levels in the 6q QTL.