Sentence examples for mapping in mice from inspiring English sources

CIA and PGIA are the two most commonly used RA models for QTL mapping in mice.

While genome-wide association studies in human and quantitative trait loci mapping in mice have provided evidence for multiple susceptibility genes, few of these have been confirmed functionally.

Traditionally, the process of gene mapping in mice is done by crossing the inbred line on which the mutation was generated with a different inbred line, and following the segregation of the mutant phenotype with known informative genetic markers.

In addition, genetic mapping in mice has indicated that DMBT1 is a candidate modifier of mammary tumors and breast cancer risk [ 41], and our results further support that allelic loss of expression in DMBT1 could contribute to breast cancer development, which is consistent with the reports from previous studies [ 42, 43].

For both ER and GR mapping in mouse, we only considered transcripts with σ>0.15 (median within-strain σ for ER mapping and between-strain σ for GR mapping), since probes with little or no variability across all samples are unlikely to show large differences in variability between subsets of samples.

In this context, high resolution mapping in mouse models are a promising approach to identifying the genes associated with trypanotolerance.

The H-2 region maps to qualitative trait loci Sle4 and Lbw1, both identified by genetic mapping in mouse models of SLE [ 46, 47].

Genome-wide wide mapping in mouse ESCs has revealed that hmC is enriched at the start sites of genes whose promoters bear histone 3 lysine 27 trimethylation (H3K27me3) and histone 3 lysine 4 trimethylation (H3K4me3) marks [ 13- 18].

In a previous study of genomic DNA 5hmC mapping in mouse embryonic stem cells (E14) ([ 73] and unpublished data), only about 2% of the mapped 5hmC sites were found to contain higher levels of 5hmC compared to 5mC using MspI and HpaII differential digestion after β-glucosylation, as in this study.

Transcriptome mapping in mouse striatum suggested three waves of gene expression following MPTP treatment: early upregulation of oxidative stress genes (Gadd45, Ddit4), intermediate (24 h) regulation of proinflammatory genes and late responses (72 h) characterized by stress response pathways (Nrf-2, Atf6, Zic1).

These 'MacGreen' mice have been used extensively in functional genomics and fate-mapping in mice (Burke et al., 2008; Ebert et al., 2009; MacDonald et al., 2010; Mooney et al., 2010; Lilja et al., 2013).