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The aim of our study is to test a cross-species genetic mapping strategy, which compares data of gene mapping in human patients with functional data obtained by QTL mapping in recombinant inbred mouse strains in order to prioritize human disease candidate genes.
In one version, based on "consistent mapping" in human visual search, target and nontarget pictures were fixed throughout training.
With advances in genotyping technologies, a breadth of high-dimensional data is now available with unprecedented numbers of genetic markers to perform association mapping in human genetics.
An r value of 0.3 indicates a sufficiently strong LD to be useful for association mapping in human studies (Ardlie et al. 2002).
For example, this approach has facilitated SNP-based genetic mapping in human [ 1, 2], Arabidopsis [ 3- 5], and rice [ 6, 7].
Here, behavioral significance was determined by the short-term context provided by the cue, analogous to "varied mapping" in human visual search.
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Recent work on statistical methods for QTL mapping in humans has included a number of methods that, though not developed specifically for discordant pairs, may well be powerful for MDSPs and possibly even EDSPs.
The prospect of using linkage disequilibrium (LD) for fine-scale mapping in humans has attracted considerable attention, and, during the validation of a set of single-nucleotide polymorphisms (SNPs) for linkage analysis, a set of data for 4,833 SNPs in 538 clusters was produced that provides a rich picture of local attributes of LD across the genome.
Two studies [37], [41] examined the cochleotopic mapping in humans along the superior temporal gyrus and showed that it may also extend, as is seen in primates, to the areas immediately surrounding the human auditory core, which may correspond to some of the belt areas.
By combining these new resources, mapping in animals could approach the speed of mapping in humans while retaining the advantages of animal experiments.
Our study suggests that the QK method [ 15] is not only appropriate for association mapping in humans, maize, and Arabidopsis but also in rapeseed, potato, and sugar beet.
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