PET-CT can map functional and metabolic activity but less accurately can identify tumour in normal sized lymph nodes.
SNPs are identified in ESTs, thus polymorphism could be directly used to map functional and expressed genes [ 1].
Positron emission tomography (PET) is an imaging technique that can map functional and metabolic activity before structural changes have taken place.
SNPs are identified in ESTs (expressed sequence tags), thus the polymorphisms could be directly used to map functional and expressed genes, rather than DNA sequences derived from conventional RAPD and AFLP techniques, which are typically not functional genes [ 7- 9].
A dense and accurate consensus map specific for T. durum will greatly facilitate genetic mapping, functional genomics and marker-assisted improvement.
We validated all the obtained hits by mapping functional domains and active site residues, yet the possibility of obtaining false positives cannot be ignored.
Future studies, including fine mapping, functional assay, and a replication study with large sample sizes from diverse ethnic populations, are needed to validate our results.
Additionally this method can reveal the biological meaning of the detected SNP combination by mapping functional modules and mapping the T2D-related information at multiple levels including disease genes.
We have provided sequence data for 302 loci in 12 accessions relevant to breeding and genetic mapping in tomato These resources should enable SNP genotyping assays for high-throughput screening of germplasm for taxonomic, genetic mapping, functional analysis and breeding.
Louis Bernatchez– (also editor in chief), research interests include genotype by environment interactions, particularly in the context of speciation studies and conservation genetics; utilizes population and quantitative genetics, genetic mapping, functional genomics, behavioural ecology and physiology.
