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Our mapping effort identified a region of 9 kb on chromosome 3, containing three complete and one partial coding sequences.
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At best, GWA studies could, in conjunction with fine mapping efforts, identify the implicated variant(s) at the level of molecular markers (e.g., SNPs).
From the Populus 34 K Infinium array-based association mapping effort, we identified seven SNPs within six candidate genes which exceeded the chromosome-wide –log10(P) = 4.46 [p = 3.47E−05 (p ≤ 0.05)] Bonferroni-adjusted significance threshold (Additional file 4).
This effort identified 661 SNPs.
Previous efforts identified 300 target genes [ 66].
The ultimate goal of our mapping efforts was to identify genes or genomic elements that maybe important to the biology of oligodendroglioma, with the caveat that such 'candidates' represent hypotheses requiring rigorous testing to establish their functional role in tumorigenesis.
A very recent association mapping effort using varieties from the japonica cultivar-group [ 21] has also identified the Saltol genomic region as controlling important aspects of salinity tolerance, as well as validating many other QTLs.
We have undertaken a quantitative trait locus (QTL) mapping effort between FVB/n (FVB) and B6 mice deficient for PECAM to identify the gene or genes responsible for this unique feature of B6 mice.
Three for schizophrenia, strokes and a circulatory illness known as peripheral arterial occlusive disease have been specifically identified.Some less practically applicable biology has come out of deCODE's mapping effort, too.
Additional strategic planning benefits of the context map include pinpointing redundancies caused by overlapping collaborative efforts, identifying gaps in coverage, and assisting the coordination of multiple stakeholders.
If two or more unique loci were identified in one contig, only the one with the longest repeat motif was chosen for mapping to avoid redundant mapping effort.
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