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Advanced intercross lines (AIL) are segregating populations created using a multi-generation breeding protocol for fine mapping complex trait loci (QTL) in mice and other organisms.
Recently, deep resequencing is emerging as a new and potent means for mapping complex trait genes.
For mapping complex trait variants, study designs that increase the number of sequenced samples by decreasing sequencing depth are more powerful and cost-effective than sequencing fewer individuals at high depth (4, 6– 8), but detection and calling accuracy at rare variant sites can be compromised.
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Isolated populations are a useful resource for mapping complex traits due to shared stable environment, reduced genetic complexity and extended Linkage Disequilibrium (LD) compared to the general population.
Thus, XPEB offers a flexible framework for mapping complex traits in minority populations.
Surveys of single nucleotide polymorphisms (SNPs) within and across dog breeds reveal haplotype structures that are ideal for mapping complex traits and diseases [18].
The admixed S. l. cerasiforme cluster is of particular interest for mapping complex traits.
In summary, GeneLink was designed specifically to ease the data management burden of mapping complex traits.
These representative studies demonstrate that QTL mapping is a realistic tool for mapping complex traits in polyploid species.
Much effort has been devoted to mapping complex traits with one or pairwise single nucleotide polymorphisms (SNPs).
Building on the successes of GWAS for mapping complex traits, considerable efforts have been invested in the development of new methods to decipher the contribution of genetic variants that have modest effects on phenotype.
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