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However, as noted in the introduction, IBD mapping cannot improve upon appropriate association testing (which may consist of rare-variant aggregation testing) in high-quality sequence data.
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There are, however, certain double-tip separations for which some of these phases take prominent Fourier coefficients to zero, thereby obscuring the current map to the extent that even CIP cannot improve it.
When the sequencing depth is low, however, the lack of sufficient reads mapping to the locus limits the power of local multiple sequence alignment and thus it cannot improve the quality of variant calls much.
"You cannot improve upon it.
You cannot improve upon perfection.
You cannot improve what you cannot measure.
But you cannot improve living standards without improving the economy.
He confessed that he cannot improve quality.
We cannot question -- which means we cannot change and we cannot improve.
Similarly, weak candidates cannot improve their chances if it does".
"You cannot improve on it; not a bit," he said.
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