Epitope mapping studies using a mutagenesis approach revealed that, whereas the epitope for rituximab lies entirely within the larger of the two extracellular loops [ 36, 37], ofatumumab binds to a motif that includes the small extracellular loop (Fig. 5) [ 35].
An MeCP2 ChIP cloning and sequencing approach revealed a number of sequences mapping to the imprinted gene cluster on chromosome 6 (Horike et al. 2005), which includes the Dlx5 Dlx6 locus.
This unbiased mapping and automated inference of directional epistatic interactions, made possible by the multivariate phenotyping approach, revealed a detailed circuit diagram of regulatory, temporal and causal relationships of complexes that function during the M-phase of the cell cycle.
The SD approach revealed considerable advantages over other approaches.
This approach revealed 439 candidate causal variants.
This approach revealed some unexpected results.
Radiation hybrid mapping is seen as an efficient technique for the generation of high-resolution gene maps in different species and RH maps can be integrated in comparative mapping approaches to reveal the degree of synteny conservation between species [ 1].
A whole-brain MVPA mapping approach might well reveal other regions that code action preparation that are not activated (or not selectively activated) in the univariate sense.
