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Power for both meiotic linkage mapping and whole genome association studies is optimized when independent breeding populations sharing a common ancestral mutation can be considered simultaneously.
All SNP mapping and whole genome sequence data is available at wormbase.org.org
The strategy of combined meiotic mapping and whole genome sequencing exceedingly reduced the effort to identify causative mutations [ 30].
Gene order is determined using one of several approaches, including physical mapping, linkage mapping, and whole genome sequencing.
Using a combined genome-wide SNP mapping and whole genome sequencing strategy, we have identified the causal mutations in 10 of these mutants.
This difference resulted in the appearance of approximately 40 probe set differences, a result later confirmed independently in our laboratory by optical mapping and whole genome sequencing [ 34].
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Cen, Z. D. et al. Fine mapping and whole-exome sequencing of a familial cortical myoclonic tremor with epilepsy family.
Through a combination of autozygosity mapping and whole-exome sequencing, we identified WDR73 as a gene in which mutations cause Galloway-Mowat syndrome in two unrelated families.
We cloned the gene containing the ku540 mutation by genetic mapping and whole-genome sequencing.
Subsequent SNP mapping and whole-genome sequencing revealed two different mutations in smc-5.
Homozygosity mapping and whole-exome sequencing were performed in a consanguineous pedigree with isolated COX deficiency linked to a Leigh syndrome neurological phenotype.
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