Dr. McKusick was the founding president of HUGO, the Human Genome Organization, a coordinating group for international genome mapping and sequencing programs, and a member of the National Academy of Sciences.
The human genome project, hailed as the biological equivalent of putting an astronaut on the moon, was progressing at an accelerating pace towards its goal of mapping and sequencing the entire human genome.
Table S3: Molecular markers used for Ghd10 mapping and sequencing.
Mapping and sequencing the breakpoint junctions revealed a novel large deletion [c.54-1161_c.164+1603del2875].
Newly developed markers and primers used for gene mapping and sequencing.
The project was divided into mapping and sequencing phases, with the idea that maps of markers ordered along human chromosomes would guide the sequencing strategy.
Because some of the partners have already begun preliminary gene mapping and sequencing, a "rough draft" of the full sequence could be completed by year's end.
Although originating and centered in the U.S., laboratories across the globe contributed to the mapping and sequencing of the haploid human genome's 22 autosomes and 2 sex chromosomes.
The NRC report, Mapping and Sequencing the Human Genome, sought to accommodate the scientists' concerns by formulating recommendations that genetic and physical mapping and the development of cheaper, more efficient sequencing technologies precede large-scale sequencing, and that funding be provided for the mapping and sequencing of nonhuman ("model") organisms as well.
However, the infrastructure of mapping and sequencing technologies developed as part of the HGP especially the ability to sequence entire genomes of organisms—has changed the way biology, not just human biology, is done.
Although the HGP's inceptions were in the U.S., it had not taken long for mapping and sequencing the human genome to become an international venture (see Cook-Deegan 1994).
