Sentence examples for mapping and mutation from inspiring English sources

It seems likely that ubiquitylation is rate limiting for CMG disassembly, although this remains to be demonstrated by mapping and mutation of the ubiquitylation sites in Mcm7.

To increase the accuracy and specificity of read mapping and mutation identification, several pre-processing filters were applied to the raw sequencing tags.

The molecular basis of Mendelian traits continues to be clarified as new technologies improve the classic strategies of gene mapping and mutation detection, producing insights with just a few patients with a rare disorder.

As sequence end pairs can be identified, the M13 (−21) sequence an adjacent barcode was computationally added to the paired end (originally corresponding to the sequence-specific reverse primer), resulting in an average of 56.8% (32,317,892) being used for read mapping and mutation detection.

The 3 maps and mutation matrix are designed to make this large dataset readable for investigators with different backgrounds such as geneticists, clinicians, biochemists, pharmacologists or protein engineers, and those who may not have any preliminary experience in homology modeling and calculations of protein stability.

Here, these phenotypes were measured, the underlying genetic loci mapped and mutations specified using a novel quantitative genetics and genomics approach.

The default parameters for the BWA mapping and Freebayes mutation calling programs missed almost all (93%) of the insertion/deletion mutation.

Detailed transcription start site mapping and experimental mutation of targeting peptides would allow us to distinguish among these possibilities in diatoms.

The SIAH1 binding site for TIEG1 has been mapped [47] and mutation of valine 205 and proline 207 to asparagines (TIEG1-NxN) results in stabilization of this protein.

However, the relative difficulty of mapping and isolating mutations has limited the number of new genetic screens.

While the power of this approach is indisputable, the effort necessary for its success remains substantial, requiring careful attention to aspects including ENU treatment, mouse husbandry, screen assay design, genetic mapping, positional cloning, and mutation validation.