Exact(22)
To identify the causal genes and to confirm whether they are allelic or not, we are undertaking high-resolution mapping and linkage disequilibrium analysis of both HWA1 and HWA2 genes.
The combination of association mapping and linkage mapping can provide both the power and resolution needed for detecting QTL of interest.
We thank Aurélie Ducasse for helping in rabbit material collection, Dr Laurent Schibler and Dr Mathieu Gauthier for their advice during the mapping and linkage analysis.
The choice of the indel provided us a simple PCR based assay for genotyping and took advantage of the difference in genetic resolution between association mapping and linkage mapping.
Su et al.[39] and other groups[41] have acclaimed the strength of combining genome-wide association mapping and linkage analysis in an F2 cross to identify QTLs underlying complex traits and avoid false-positive loci.
In conclusion, we have combined genome-wide association mapping and linkage analysis to identify and validate two novel loci that modulate response to systemic C. albicans infection in mice.
Similar(38)
Their applications in biology as genetic markers are related to numerous fields ranging from paternity analyses to construction of genetic maps and linkage to human disease.
The manual check of the potential assembly or mapping error warrants the correctness of both physical map and linkage map in the next step.
The map distance between binned markers is zero, and this information is needed to minimize the error between the consensus map and linkage maps (see below).
The comparison of our annotated linkage maps and linkage maps reporting QTL information revealed 11 annotated SNPs in candidate genes that co-localized with previously reported QTLs for wood properties and water use efficiency.
The comparison of our annotated linkage maps and linkage maps reporting QTL information revealed candidate genes for several QTLs for wood properties or isotopic composition of C (δC) [ 61, 62, 64].
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