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MY carried out genetic mapping, analyzed the data, and drafted the manuscript.
JSX carried out genetic mapping, analyzed the data, and drafted the manuscript.
In any event, the PrPC central region defined by genetic mapping (analyzed by CGN assays in this paper, see also Lee et al, 2006) is natively unstructured in NMR studies (Donne et al, 1997; Riek et al, 1997) and the homologous region in Sho is likely to be natively unstructured as well.
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