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We conducted QTL (Quantitative Trait Locus) and admixture mapping analyses on two controlled crosses and on an artificial admixed population, respectively, all obtained from resistant and susceptible lab strains.
We repeated the eQTL mapping analyses on permuted gene expression data sets to empirically estimate FDR.
BA and SL carried out the preliminary QTL mapping analyses on backcross families.
Discrete-trait mapping analyses on more intensively sampled data sets could help to shed light on the selective forces underlying rates of gain and loss of resistance determinants in the future.
Using single- and multiple-QTL mapping analyses on each pedigree and on the combined pedigree, we investigated the benefits of combining pedigrees (i.e. doubling the pedigree size) to refine the location of QTL for growth and fatness on SSC2, 4 and 6.
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We took advantage of the intraspecific polymorphism, in a novel design, to perform quantitative trait locus (QTL) mapping analyses directly on F1 hybrid male sterility itself.
Notably, a tryptic glycopeptide derived from the highly conserved N-terminal region of the mucin-like domain (313-QIHATPTPVTAIGPPTTAIQEPPSR-337) has not been covered in most mapping analyses performed on α-dystroglycan.
We used a commercial half-sib population of 518 Spanish Churra ewes with available data for fecal egg counts (FEC) and serum levels of immunoglobulin A (IgA) to perform different genome scan QTL mapping analyses based on classical linkage analysis (LA), a combined linkage disequilibrium and linkage analysis (LDLA) and a genome-wide association study (GWAS).
SJL provided an initial sequence alignment, performed preliminary mutational mapping analyses and provided guidance on the study.
Transcriptome mapping analyses have been based on data generated from a variety of experimental techniques, including Expressed Sequence Tags [ 9], Serial Analysis of Gene Expression [ 8], and microarray [ 7].
In some cases, mapping analyses were carried out on 173 additional animals available from other projects that are not descended from ancestor A0.
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