Traditionally, map-based cloning utilizes DNA-based markers that have been mapped to fairly precise areas of plant genomes.
Such genotypes map to precise genomic locations, and provide information on both copy number and base residue.
Moreover, because clusters of cis-eQTLs would all map to precise genomic regions, further analysis of these regions might reveal the nature of the polymorphisms associated with coordinate changes in gene expression.
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Importantly, sequence matching to the human genome database revealed that approximately 85% of the virtual tags mapped uniquely to precise chromosomal locations (Additional file 7b, c).
By use of a breakpoint spanning PCR, we then mapped the precise breakpoints to 134,764,601 bp (last preserved base, proximal breakpoint) and 134,879,936 bp (first preserved base, distal breakpoint), indicating a deletion size of (exactly) 115,334 kb.
While their experiment was designed to mapping the precise neural mechanisms of high-level attitudes and beliefs, their results show that the same technique could be used to trigger a wide spectrum of alterations of a person's attitudes and beliefs.
The tandem repeats of vertebrate centromeres are an obstacle to mapping the precise DNA locations of inner kinetochore proteins on centromeric DNA and resolving this apparent contradiction.
To test this hypothesis, we first verified the AMOT/Merlin interaction and mapped their precise binding domains using high-quality, purified recombinant proteins.
We first mapped the precise location where Xrn1 is blocked by DVxrRNA1.
