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To understand how this drives signaling, we have used advanced analytical methods that enable separation of effects on pathway-specific signaling from those that modify agonist affinity and mapped the functional consequence of receptor modification onto three-dimensional models of a receptor-ligand complex.
Mutational analysis and NMR titrations have mapped the functional interface to a contiguous surface.
Biochemical and biophysical studies on NP, the main component of viral nucleocapsid, defined the boundary between N-terminal and C-terminal domains and mapped the functional region responsible for NP-NP interaction to be within the first 450 amino acids (Watanabe et al., 2006; Noda et al., 2010).
Using this approach, we have mapped the functional interaction between the MID1-α4-PP2A MID1-α4-PP2A MID1-α4-PP2Aion between amino acomplex and 1100 (FiGLI3).
However, when we mapped the functional effect of alanine mutants onto the structure of the N terminal α helix, the residues with perturbed function did not lie along the entire length of the α helix (Fig. 6C).
To visualize and quantify the symmetrical layout of the sensorimotor activation, we mapped the functional data to transformed, 2D views of the pre- and postcentral gyri (Fig. 4, top, showing the same two experiments as in Fig. 3).
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We provide examples of mapping the functional values of habitats for populations of three commercially important species.
A research collaboration involving Stephen Kosack, Michele Coscia, Evann Smith, Kim Albrecht, Albert-László Barabási, and Ricardo Hausmann generated a new way of empirically mapping the functional structures of governments.
Mapping the functional roles of the cationic amino acids of the major antimicrobial region of LL-37 provides a basis for designing antimicrobial peptides with desired properties.
This idea can be tested by mapping the functional organization of the nidopallium and the connecting arcopallium between the auditory and posterior movement-associated areas in parrots relative to other species.
Thus, the component images map the functional connectivity of constituent regions activated during neural stimulation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com