Our strategy is divided into two steps: first, monomers are mapped on the atomic structure by an efficient subgraph-isomorphism algorithm ; second, the best tiling is computed so that non-overlapping monomers cover all the structure of the target polymer.
We design dedicated algorithms and data representation for the two steps of s2m: first the monomers of the database are mapped on the atomic structure, second the best tiling is computed so that non-overlapping monomers cover all the polymer structure.
Early on, researchers struggled to map the atomic structure of even one of these subunits.
The resolution is so sharp that it rivals images produced by x-ray crystallography, long the gold standard for mapping the atomic contours of proteins.
Researchers report that they've created a cryo-EM image so sharp that it rivals images produced by x-ray crystallography, the gold standard for mapping the atomic contours of proteins.
Mapping the mutations onto the atomic structure of BbCRASP-1 reveals that, in contrast to earlier assumption, the C-terminal mutations act indirectly on FHL-1 and factor H binding, whilst the region 1 mutations map the site of direct complement regulator interaction.
We developed a fast fitting program, " gmfit", which employs a Gaussian mixture model (GMM) to represent approximated shapes of the 3D density map and the atomic models.
We know from our friends at Knewton what the Grand Design is -- a system in which student progress is mapped down to the atomic level.
Among the items known to be missing are Lincoln telegrams from the Civil War, patents for Eli Whitney's cotton gin and the Wright brothers' flying machine, target maps for the atomic bombing of Hiroshima and Nagasaki, the "only known copy" of the Potsdam Declaration signed by President Harry Truman at the end of World War II, and more.
With increasing tilt angle from a zone axis, the shell is expected to look qualitatively thicker in EDX maps, as the atomic columns become less parallel to the incident electron beam direction.
