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Since the Disease Ontology [13] has already mapped terms to various public disease identifiers, we adopted Disease Ontology ID as primary ID.
One important phenomenon in post-coordination is the identification of relationships between the mapped terms.
Drug and condition prevalence comparisons between selected mapped terms in the CPRD CDM and the CPRD raw data were equivalent.
All the drug and disease mapped terms, as well as all the mapped gold standard drug-disease relationships are available for download at (http://meshop.oicr.on.ca/meshop/).
Notably, these cancers also differ in the extent of the available treatment evidence-base; MEDLINE searches (15 February 2011) using mapped terms returned 124 548 articles for 'breast cancer' and 77 488 for 'sarcoma'.
Overall, normalised matching mapped 3,266 (44.08%) terms, Expanded String Matching further mapped 304 (4.10%) terms, WordNet Matching give another 92 (1.24%) newly mapped terms, and Substring Matching increased by 809 (10.88%) the matched terms.
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For this reason, the modern curator is involved in codifying terms (providing a unique identifier to a term and all its synonyms), and mapping terms between different nomenclatures.
A noteworthy amount of scientific papers applies techniques for the recognition of concepts, mainly by mapping terms from the texts to UMLS concepts (e.g. [ 30- 33]).
Due to the hierarchical tree of the gene ontology (GO) terms and redundancy of the terms, we mapped GO terms against representative gene function.
It also provides additional search information such as mapped MeSH Terms, mapped Subheadings and unmapped terms.
To determine the function of differentially expressed genes, all DEGs were mapped to terms in the GO database.
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