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The specific pathways, including "spliceosome," "purine metabolism," "ribosome," "RNA transport," "starch and sucrose metabolism," and the other 20 top mapped pathways were shown in Figure 5.
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The list of the mapping pathways is shown in Table 1.
The mapped HIF pathways were quantitatively illustrated and evaluated by statistically analyzing their conserved transcription factor-binding elements.
For each disease, the fraction of disease associated genes statistically mapped to pathways was calculated and its distribution over 605 diseases is shown in figure 1c.
Complex and as yet incompletely mapped signalling pathways are responsible for the precise spatiotemporal regulation of cellular actomyosin.
The nuclear translocation of NF-κB and the phosphorylation level of Akt, p38 and JNK MAP kinase pathways were also inhibited by TL2 in LPS-treated BV2 microglia.
MAP kinase pathways were studied by western blotting according to standard procedures as described previously [ 22, 23].
Since several pathways were mapped to more than one dataset, these pathways could be ascertained with high confidence.
Biological pathways were mapped and sorted on the order of matching significance using ArrayXPath [ 47].
Closer scrutiny of this interaction map reveals that MAP kinase pathways are over-represented (Fig. 1B, see figure legend for details).
The mitogen-activated protein kinase (MAP kinase) pathways are found in bovine parathyroid cells [9].
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