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We also observed that several probands mapped outside the primary proband cluster (branch 1).
The 10% of values outside that limit (i.e. the tails of the distribution) are mapped outside the 90% environmental envelope [ 5].
The remaining three samples obtained at day 4 postinfection mapped outside the Hotelling 95% confidence ellipse caused by much higher concentrations of lactate and pyruvate (4- and 1.75-folds greater than the mean of other infected animals at day 4, respectively).
Because of limited resolution of the array CGH, we carried out Sanger sequencing and this confirmed that CDKN1B was deleted in its entirety on the maternal allele, with the 5′ breakpoint mapped outside the coding region of GPR19 (data not shown).
Type 1 diabetes (T1D) exhibits strong clustering in families, and yet the major effect, human leukocyte antigen (HLA) gene polymorphisms in the major histocompatibility complex (MHC), and over 50 other loci mapped outside the MHC (19– 28), do not fully explain the familial aggregation.
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Moreover the 18q breakpoint mapped outside from the critical region defined from deletion mapping (Fig. 1a).
These effects may indicate gene expression regulation in cis, whereas differentially expressed genes that map outside the congenic interval undoubtedly reflect effects in trans and are secondary adaptations to defects caused directly of indirectly by genes in the congenic region of GK origin.
However, we also observed clusters mapping outside the typical promoter region 2 kb upstream and 200 bp downstream from TSSs.
Nine class I genes with complete open reading frames were found on the BACs, which map outside the MHC to 9 chromosomal locations.
It is noteworthy that all the s* mutations are probably not simply preventing the production of a functional mRNA, but are also not preventing the production of an active protein, as they map outside the evolutionarily conserved region of the protein.
The only haplotype (RR) that mapped outside of the two haplogroups clusters was probably a recombination product between haplogroup 1 and haplogroup 2. To test whether the number of predicted SDHA haplotypes in the African American samples is compatible with neutral evolution, we employed the Depaulis and Veuille haplotype number test [ 36].
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