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Table 2 shows the mapped gene list, along with a numerical score for each (mapped) gene, representing the level of similarity between the two protein domain structures.
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In SAMMD, such duplicate entries were removed from the extracted and mapped gene lists.
To compare to CREB target genes from previous genome-wide studies, we mapped gene lists onto our current RefGene annotations using both gene symbols and by overlapping genomic coordinates, to avoid any bias from updated gene annotations.
The EST VNTR markers are also directly mapped genes that are listed in Additional file 1 with their putative functions.
The positions of the mapped genes within the contigs are also listed.
For the input of a gene set into IPA, its core analysis tool will map the gene list to the IPKB and then algorithmically generate molecular networks, biological functions, and canonical pathways that are most likely relevant to the input gene list.
To investigate this we mapped our gene lists to Ensembl genes with BioMart [ 53], and extracted the splicing isoform information from the ASD database [ 54, 55].
Secondly, we mapped our core gene list to the entire knowledge base, so that all of the gene-disease associations corresponding to the provided genes could be extracted; one gene may be involved in several diseases, and one disease may involve numerous genes.
We excluded genes that could not be mapped to the gene list G and removed gene sets with less than ten genes.
A map and gene list for the described microarray platform is available at Gene Expression Omnibus website, accession number GPL1930.
Briefly, this tool maps the gene list of interest to the Panther ontology and compares to the selected reference gene list to identify over- and under-represented terms.
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