So the final classification map is acquired.
Prior to acquiring the DCE-MRI image series, a saturation recovery T1 map was acquired using a spin echo sequence with varying TRs, settings: TE = 8 ms, TR = 200, 400, 800 and 1600 ms.
Another energy-filtered map was acquired at 3.4 eV; the result is a glow around the NP which corresponds to the well-known dipolar mode for silver nanospheres in air [21].
First, a T2 map was acquired and then a series of H density weighted images were recorded each hour during the first 60 consecutive hours.
The macular thickness map was acquired with the integrated software 6.0.0.599, which centred on the automatically identified foveal pit and was manually corrected if needed.
This IR map was acquired via 2 × 2 pixel binning in order not to compromise the spatial resolution for the sake of revealing smaller BV features.
A smooth spatiotemporal area map was acquired for quantifying LV. Figure 5 shows two typical examples of the most apical slice estimation and the most basal slice segmentation.
Furthermore, a field map was acquired using a gradient echo imaging sequence (2 × 2 × 2 mm voxel size; 65 slices; echo time 1/echo time 2/repetition time = 5.19/7.65/655 msec) to account for distortions caused by field inhomogeneities.
Furthermore, a field map was acquired using a gradient echo imaging sequence (2 × 2 × 2 mm voxel size; 65 slices; echo time 1/echo time 2/repetition time = 5.19 ms/7.65 ms/655 ms) to account for distortions caused by field inhomogeneities.
For perfusion quantification, a separate T1 map was acquired using inversion recovery and the same spin-echo EPI acquisition with TR = 10 sec and TI = 10, 100, 500, 1000, 2000, 5000, and 8000 msec (two averages and total imaging time of 4 min).
