MaP was involved in data collection, study design, data analysis and interpretation, and drafting of the manuscript.
MAP was involved in the project conception, designed experiments, carried out RNA extraction, performed qRT-PCR and Western blot analysis, performed data analysis, analyzed Illumina data, and drafted the manuscript.
CHF, SSS, EH, MVR and MAP were involved in editing drafts of the manuscript.
Additionally, 36 assigned metabolites could be mapped being involved in 99 toxicity functions (Supporting Information Figure S-17 and Spreadsheet S-3), such as liver damage, cardiac damage, and renal failure.
bCellular processes with at least four maps are high-lighted in bold The most prominent transcriptomics-based maps were involved in metabolic processes with amino acid metabolism on top followed by lipid metabolism, steroid metabolism, metabolism of mediators and vitamin and cofactor metabolism.
The cellular processes in which these 73 pathway maps are involved are presented in Table 3. Cross-omics analysis revealed amino acid metabolism, lipid metabolism, GPCR signaling, Vitamin and cofactor metabolism and transcription to be the cellular processes most dominantly affected in HepG2 by TCDD exposure.
We investigated whether the MAPK signaling pathway, including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAP kinase, was involved in the neuroprotective effects of LPE against H2O2-induced cell injury.
MJW performed the phylogenetic and stochastic mutational mapping analyses, was involved in the study design and drafted the manuscript.
LL performed the phylogenetic and discrete trait mapping analyses, was involved in the study design and drafted the manuscript.
IAO collected the field data, made substantial contribution in data analysis and interpretation, created the maps and Figures, was involved in the design and scoping of the project, edited the draft manuscript.
Lan et al. [ 26] found that induction of p-ezrin via the p38 MAP kinase signaling pathway was involved in the formation of microvilli during development of epithelial cell polarization.
