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Interestingly, exceptions mainly map to the active site cleft.
The missense mutations p.C373S and p.W325C map to the active domain of BMP4.
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The idea is to use the saliency map to initialize the active contour.
For PowerUp, only one core is active and thus all runnables are to be mapped to the only active core.
Figure 3(b) represents the best AChE pharmacophore model aligned with the most active AChEI with IC50 of 0.3 nM, which shows that pharmacophore features are mapped well to the active compound.
"He was referring to a new project to map the active human brain that the N.I.H. hopes to fund next year".
To map the active sites to as many Mtb protein domains as possible, each PDB_ID in CSA was assigned to PFAM domains.
To map the active site residues to as many Cp protein domains as possible, each PDB_ID used as a template for the homology modelling in CSA was assigned to the modelled ORFs.
These compounds were also used to design pioneering molecular modeling techniques used to map the active site of aromatase [ 70, 72].
Highly conserved residues (>85% identity between all taxa) invariably mapped to the previously identified active site pocket (Martinez-Fleites et al., 2009).
To understand the cell type-specific regulation of the alternative metabolic pathways we built multiple models during differentiation of primary human monocytes to macrophages and performed ChIP-Seq experiments for histone H3 K27 acetylation (H3K27ac) to map the active enhancers in macrophages.
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