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Among trans-mapping effects, only a minority map to loci containing TFs.
By our selection criteria, the two partners of a chimeric sequence map to loci on two different chromosomes.
Simply put, the selection of chimeric sequences consists of selecting queries (EST or mRNA) that map to loci on two different chromosomes.
let-7 is therefore considered to be a tumor suppressor miRNA and, interestingly, let-7 genes map to loci deleted in multiple types of cancers, including ovarian cancer [20].
Of these, seven map to loci where common variants probably influence HbA1c levels via erythrocyte biology.
Exploration of the 57,308 RNA DNA hybrids mapping to intergenic regions revealed 11,825 to map to loci where GRO-seq indicated transcription.
Similar(53)
Four additional genes required for systemic RNAi have been reported (rsd-2, -3, -4 and -6) [ 26], but none of them map to locus ZK721.1.
The percentage of mapped reads mapping to loci of annotated RTEs are shown to the right.
It maps to loci that have previously been shown to be involved in local adaptation to climate.
We directly replicated five previously reported European variants (P<0.05; mapping to loci harbouring FASLG/TNFSF18, SCHIP1/IL12A, PFKFB3/PRKCQ, ZMIZ1 and ICOSLG).
The seven most abundant candidates all mapped to loci that were annotated as tRNA or rRNA except Fc-2 (Additional file 2), although some also mapped to other loci that were not annotated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com