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The four analog mechanisms map to enzyme induction, enzyme elimination, drug metabolism, and enzyme-substrate binding.
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Major ES proteins map to enzymes, which are essential for metabolic pathways functioning and also very well reflected in our protein domain mapping.
Reactions were mapped to enzymes and enzymes mapped to their corresponding genes using the association tables from KEGG.
In R2, the molecules in tp:reactants and tp:produces are mapped to enzymes and output entities in CSML, respectively.
Enzyme mapping of annotated sequences was performed using direct GO to enzyme mapping and used to query the Kyoto Encyclopedia of Genes and Genomes (KEGG) to define the main metabolic pathways involved [ 68, 69].
Mapping from GO terms to enzyme codes permits the subsequent recovery of enzyme codes and KEGG pathway annotations.
Binders map to transporters, enzymes, lysosomes, and other cellular material that binds or sequesters drug molecules.
GO terms were directly mapped to their enzyme code equivalents in the BLAST2GO Java application (http://www.blast2go.com/b2ghome) in order to generate enzyme code and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway annotations thus identifying which metabolic pathways the gene products are involved in.
GO terms were then used to map enzyme codes to each sequence.
RiceCyc version 3.3 features 316 pathways and 6,643 peptide-coding genes mapped to 2,103 enzyme-catalyzed and 87protein-mediatedprotein-mediatedtions.
The Table shows all unigenes that are mapped to specific enzymes and gene regulation patterns either up-, down-regulated or both.
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