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Noteworthy, both ATM and MEN1 map to chromosomal arm 11q, which is frequently lost in PET [ 52].
Moreover, their genetic localisations (Aurora-A, 20q13; Aurora-B, 17q13) map to chromosomal loci frequently altered in tumours.
More recently, tissue specific patterns of gene expression have been shown to map to chromosomal domains [ 22].
Sequence-tagged site genetic markers incorporated in the genetic map anchored the euchromatic portion of the physical map to chromosomal loci.
Many of these genes map to chromosomal regions previously identified by genetic analyses as harboring autism susceptibility genes or QTL, thus demonstrating the potential of combined genomic-genetic analyses to prioritize autism candidate genes for further genetic and functional analyses.
Unlike Mendelian disorders, however, which can often be traced to mutations that disrupt gene structure or coding sequences, genetic markers that associate with complex disorders often map to chromosomal sites located outside of gene coding regions [ 8].
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The human gene for enzyme 5, 10-MTHFR has been mapped to chromosomal region 1p36.3 and consists of 17 kb, including 11 exons spanning 2.2 kb.
All interacting QTLs were mapped to chromosomal regions different from additive QTLs.
Several clusters of NBS genes mapped to chromosomal regions where genetic resistance to fungal diseases, such as downy and powdery mildew, were previously assigned (Figure 3B).
The genomic locations of the P. falciparum orthologues were, in turn, used for physical mapping to chromosomal locations in the genome of P. c. chabaudi through the conserved genetic synteny between the human malaria parasite P. falciparum and rodent malaria parasites [33].
Fewer MeDIP-seq reads mapped to chromosomal regions where gene density was higher (Additional file 8).
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