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Mutmap-like strategy and extreme linkage analysis were then applied to fine map this locus within 1.14 cM.
The sequence of wPt-0223 was used to map this locus in silico at position 2,170,833 bp (i.e. 0.53 Mb proximal of marker cfp5031), just outside the interval predicted in 3B-RH.
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Here, we used ancestral haplotype analysis to fine-map this locus to 12 candidate genes.
We further tested all markers in this region (approximately 500 Kb regions upstream and downstream of BIN1) in QFP and combined all available samples/data (Pfizer, ADNI, GenADA, the replication Genizon samples and the published Harold data set) to fine-map this locus.
Fine mapping this locus in the AJ and African-American populations could help shed light on this question.
Fine mapping this locus and describing its structure thus understanding the sex determination of kelp gametophytes will be the focus of our future studies.
Based on a resequencing analysis of a 56 kb region on chromosome 19q13.33, centered on the KLK3 gene, we fine mapped this locus by genotyping tag SNPs in 3,522 prostate cancer cases and 3,338 controls from five case control studies.
A region on the right arm of chromosome 3 that is linked to e had the greatest effect, and recent work has fine-mapped this locus to the interval bounded by ∼3:26,136,000 and ∼3:26,315,000 (Hungate et al. 2013).
Fine mapping this locus with three CAPS markers derived from the actual MIP genes themselves or sequences nearby did not improve the linkage obtained with the two most closely linked SSR markers.
Furthermore, two putative DNA methylases (SCO6844 and SCO6885) also map to this locus.
A further refinement of the map of this locus is needed to reduce the size of the chromosomal region functionally linked with modulation of lung tumor size and, consequently, the number of candidate genes.
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