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This includes the option to map the query sequence of interest to any of the known tardigrade specific COGs.
Finally a mapping engine is built on the kernels derived from the neural response algorithm to map the query protein to its most probable GO term.
The higher the abstraction level, the harder usually it is to parse and map the query on the underlying database schema.
Furthermore, DASMIweb will map the query to all compatible identifier systems in order to maximize the number of data sources that can be used to answer the user query.
Fifth, when the query sequence is from a user-specified organism with available complete genome sequence, MESSA will map the query to its genomic locus by BLAST and show the genomic context of the query through NCBI E-utilities.
To quantize the similarity between pairs p i and p j, we encoded the pair (p i, p j) into a vector N (i, j) on which we can formulate the mapping engine to map the query protein to its most probable GO term.
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Thus, a tool provided with a query like the one in Figure 1 should carry out, at least, two steps: first, successfully interpreting the meaning of childhood-onset chronic diarrhea and second, adequately mapping the query to the dataset.
Since the comparison needs to be performed in the same space, the query expansion is performed by mapping the query vector to the Eigen space as shown in Eq. 4. (4) q = q 0 T U s ∑ s − 1.
To determine the structural effects PolyPhen also does a BLAST query of the input protein sequence against PDB and PQS structure databases and maps the query substitutions to known 3D structures.
We used Gene Ontology (GO) vocabulary for protein functional assignment, i.e. we mapped the query protein to its corresponding GO term(s) that represent(s) the properties of the query sequence.
We first mapped the query proteins to the oyster genome with TBLASTN [ 33] (E-value ≤ 0.01), and excised target-gene regions with 2-kb flanking sequences for gene structure and protein sequence determination using GeneWise [ 34].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com