Using the NC16A+/+ mice and BP patients' sera, we mapped the pathogenic epitope of BP180 in vivo [ 39].
Indeed, the identification of RGCs as the cells of origin for ependymoma was a significant breakthrough towards mapping out the pathogenic mechanisms of ependymoma.
Ketamine's illicit status makes this a difficult patient group to study, and so the full extent and incidence of the problem within the population is unknown, and poor documentation of ketamine usage with respect to the development of functional/structural bladder changes has hindered the causal and staged mapping of the pathogenic pathway.
To establish a structural basis for inherited MAT1A deficiency, we mapped the reported pathogenic mutations, including 30 missense mutations (see Supplementary Table S2 at http://www.biochemj.org/bj/452/bj4520027add.htm), in the hMAT1A structure.
The pathogenic road map leading to Alzheimer's disease (AD) is still not completely understood; however, a large body of studies in the last few years supports the idea that beside the classic hallmarks of the disease, namely the accumulation of amyloid-β (Aβ) and neurofibrillary tangles, other factors significantly contribute to the initiation and the progression of the disease.
The proteomic map of pathogenic trypanosomatids has been assessed for the identification of virulence factors and stage-specific proteins and even for the characterisation of immunogenic molecule candidates for vaccines or diagnosis.
Mapping of ESTs from the reference and an additional pathogenic isolate, SO3-P (Andrie et al. 2007), resulted in a greater number of mapping events than the number of input transcript reads, which indicated that there are transcripts of repeats being produced in the pathogenic isolates that map multiple times to the reference genome (Table S6).
Reads from the pathogenic DW7-ToxB map to these NPSs, but it is difficult to determine if the domains and modules are arranged in a similar manner due to the difficulty of assembling highly similar reads.
In this study, we evaluated the functional significance of 47 MUTYH variants by an analysis of E. coli complementation, protein stability, and subcellular localization in mammalian cells to enhance our understanding of the pathogenic effects in MAP.
To further elucidate the pathogenic potential of MAP for the development of IBD and its significance in healthy individuals, it seems inevitable to transfer the results of the observed association of MAP and IBD to more functional studies in the future.
