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Modern non-invasive imaging techniques utilize the coupling between neural activity and changes in blood flow, volume and oxygenation to map the functional architecture of the human brain.
Characterization of these heterodimers, by activity assays and chemical cross-linking, has been exploited to map the functional topology of the protein.
For interaction between humans and automation systems it is crucial to map the functional properties of the system onto the intentions pursued with its development.
Individualizing cancer therapy for molecular targeted inhibitors requires a new class of molecular profiling technology that can map the functional state of the cancer cell signal pathways containing the drug targets.
Genetic networks are the result of a systematic strategy to map the functional associations characterizing a biological system by means of perturbations (Fig. 1).
We have used fMRI to map the functional substrates of OX1R or OX2R blockade in the rat brain using GSK1059865 and JNJ1037049, two novel and highly-selective OXR antagonists.
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Constructing chimeras between functionally distinct yet structurally homologous receptors is a unique approach to mapping the functional determinants of proteins.
Mutational analysis and NMR titrations have mapped the functional interface to a contiguous surface.
He/She then maps the functional hierarchy into a metamodel using physical features that are building blocks for conceptual design.
Mapping the functional roles of the cationic amino acids of the major antimicrobial region of LL-37 provides a basis for designing antimicrobial peptides with desired properties.
These results, which demonstrate the strong influence of tonal amplitude on activation levels, identify sound intensity as an important adjunct parameter for mapping the functional architecture of auditory cortex.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com