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Importantly, the assessment of genetic structure is required to map the causal genes responsible for observed natural variation in ecologically important complex traits by genome-wide association analysis to reduce spurious correlations between genotype and phenotype [16].
The Asian-specific risk variants in G6PC2 may help to fine map the causal region within the gene (or possibly the G6PC2-ABCB11 regiven given the proximity and strong linkage disequilibrium between the two genes).
We applied bulk segregant analysis to map the causal locus of the Mal- phenotype.
Several S. pimpinellifolium accessions are known to confer resistance to the virus [ 19– 24], but attempts to map the causal factor in this species were not very successful.
Maitreya Dunham (University of Washington) presented a clever genetic approach leveraging the Saccharomyces cerevisiae deletion collection to map the causal genes within long-known segmental duplications that emerge from nutrient-limitation experiments.
As shown in Figure 2, the theory of change allows us to map the causal chains between supply- and demand-side incentives and to identify some of the expected intended and unintended effects.
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Mapping the causal allele or alleles for a particular trait is one of the most common methods for learning about the genetic processes underlying biological function.
The underlying idea is to use the RI population-based data for identifying potentially causal loci and then use the high-resolution data for 'fine mapping' the causal gene.
We will capitalize on the large sample size and conduct conditional analyses to help fine-map the causal variant within a region showing multiple significant associations.
Differences in LD architecture encompassing the variants among different populations may help to fine-map the causal variant if shared across ethnicities, as shown in Palmer et al. (8).
We mapped the causal locus for these phenotypes and found that CS3227 harbored the gi-1 mutation, a 5-bp deletion in the GIGANTEA gene.
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