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We plotted these values as a heat map tested for the numbers of significant tests for departures from homogeneity using a χ test.
S-MAP tests for significant stemness-associated expression of a particular gene or module by computing three scores – recurrence, specificity, and diversity (Figure 1).
To identify trans regulatory associations, creQTL mapping tests for the association between genetic variants spanning the genome and clusters of co-regulated genes.
Association mapping tests for an association between a set of genome-wide single-nucleotide polymorphisms (SNPs) and a specified phenotype, with the expectation that one or more of these SNPs may be linked to the causal variant(s).
Statistical parametric mapping testing for the psychophysiological interaction was masked first with the putamen mask, and then the thalamus mask (of the same hemisphere).
Genome-wide fine mapping was conducted by linkage disequilibrium mapping, testing for the significance of association between expression levels and inferred haplotype descent at each locus, as previously described (Solberg Woods et al. 2010, 2012).
Computational genetic mapping testing for robustness- To assess the robustness of HBCGM using different subsets of input strain data, we developed software that could automatically perform a re-sampling analysis.
Table 6 demonstrates the framework used in this study for mapping tests within the TNB and CNB to various neurocognitive domains.
Other supporting data (map position and annotation for linkage mapped transcripts, tests for association with sex) are included in the additional files section.
A fecal sample of each animal of one year of age or older was collected for MAP testing.
WebQTL was used for linear regression analyses, composite and interval mapping and tests for epistatic interactions available at The GeneNetwork (www.genenetwork.org).org
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