Sentence examples for map of nucleosome from inspiring English sources

They established a genome-wide map of nucleosome locations and the map shows which region in the genome is occupied by nucleosomes.

Previous studies analyzed the dependence of nucleotide substitution rates in the yeast genome by comparing their positions on a map of nucleosome locations [ 9, 25].

Jiang and Pugh developed a compiled reference map of nucleosome positions in Saccharomyces cerevisiae, using multiple maps independent of our study (Jiang and Pugh 2009a, b).

We chose yeast because we wanted to compare the predictions to a base pair resolution map of nucleosome positions in yeast (Brogaard et al., 2012).

More recently, a complete high-resolution map of nucleosome occupancy across the whole genome of yeast has shown that 81% of the yeast genome is covered by positioned nucleosomes [ 27].

The resulting reads, mapped to the mouse genome, allowed the generation of map of nucleosome occupancy at high 27-35XX) coverage for each cell type (Additional file 1: Table S1, Additional file 2: Figure S1).

Detailed histone modification profiles on positioned nucleosomes near TSSs revealed interesting patterns, some of which could not be observed previously without the map of nucleosome-resolution modifications.

Furthermore, because the 3D map of nucleosome-bound SWR1 was obtained in the absence of nucleotides, it remains to be seen how ATP binding and/or hydrolysis by Swr1 and perhaps Rvb1/Rvb2 may further affect the overall structure of the substrate-bound complex.

We have found that nucleosome occupancy predictions of these models are highly correlated with the predictions of the same model trained on a high-throughput map of nucleosomes assembled in vitro on genomic DNA from a single-cell eukaryote S. cerevisiae [ 27].

Genome-wide mapping of nucleosome positions and correlation of genome-wide nucleosomal remodeling with the changes in the gene expression can help us understanding gene regulation on genome level.

Here we discuss the large-scale maps of nucleosome positions made available through recent advances in parallel high-throughput sequencing and microarray technologies.