In the present study, we perform FAIRE-seq using samples from the silk glands of silkworm larvae and BmE cells, generated a map of genome-wide OCRs, discovered motifs present in these OCRs, and analyzed the regulation modes of TFs and their target genes, especially for the silk protein genes.
High-density map of genome-wide graphic genotypes was constructed using single nucleotide polymorphism SNP markers as described previously (Gao et al., 2013).
In yeast, the role of chromatin-remodelling enzymes, such as isw2, has extensively been studied and a map of genome-wide nucleosome positions in an isw2 deletion strain has been reported in the 'additional data file 1'.
This is a generic strategy that can readily be applied to elucidate conditionally active gene regulatory networks in any organism, just from a map of genome-wide TF-DNA binding locations and a compendium of transcriptome profiles from diverse environments.
This present study employed systems physical network approaches [ 17] and constructed a comprehensive and unbiased map of genome-wide interactions between miRNAs and their targets to investigate the global basis of miRNA roles in pluripotent stem cells, from the pluripotent self-renewal state to the differentiation state.
Comprehensive maps of genome variability and population structure would facilitate genome-wide association studies of complex traits, functional gene investigations and the selection of appropriate donors for breeding purposes.
Thank you for submitting your work entitled "A simple method for generating high‐resolution maps of genome wide protein binding" for peer review at eLife.
Microarray-based comparative genomic hybridization allows the construction of high-resolution maps of genome-wide copy number alterations.
The mapping of genomes, he said, inspired scientists to use the same approach in studying proteins, metabolites and their biochemical connections, to name a few.
