Recent advances in systems biology enable illustration of a cell-wide map of complex molecular interactions by using the literature-based knowledgebase of molecular pathways.
The 2.8-Å resolution structure of dimeric complex IV from bovine heart mitochondria (Tsukihara et al, 1996) and a 6-Å map of complex I from Yarrowia lipolytica (Hunte et al, 2010) have been reported.
Recent advances in systems biology have made major breakthroughs by illustrating the cell-wide map of complex molecular interactions with the aid of the literature-based knowledgebase of molecular pathways [ 7].
Recent advances in systems biology have made a great breakthrough by illustrating the cell-wide map of complex molecular interactions with the aid of the literature-based knowledgebase of molecular pathways [ 12].
The 6-Å map of complex I from Y. lipolytica (Hunte et al, 2010) (provided by Carola Hunte, Universität Freiburg) was fitted to the clear features of the matrix arm and on the intermembrane side in the supercomplex map.
The eight conserved clusters are ligated by a set of conserved sequence motifs; they have been defined structurally in the hydrophilic domain of Thermus thermophilus complex I and observed also in an electron density map of complex I from Yarrowia lipolytica.
