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PET-CT can map functional and metabolic activity but less accurately can identify tumour in normal sized lymph nodes.
SNPs are identified in ESTs, thus polymorphism could be directly used to map functional and expressed genes [ 1].
Positron emission tomography (PET) is an imaging technique that can map functional and metabolic activity before structural changes have taken place.
SNPs are identified in ESTs (expressed sequence tags), thus the polymorphisms could be directly used to map functional and expressed genes, rather than DNA sequences derived from conventional RAPD and AFLP techniques, which are typically not functional genes [ 7- 9].
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This can be observed by phylogenetically mapping functional and expression information collected from studies on Arabidopsis proteins [ 6, 7, 17- 23].
Great efforts have been made to map functional DNA elements and epigenetic modifications genome-wide [23], [24].
They are of particular interest to study the genetics of expressed genes and to map functional traits.
For that, we first select a representative in each superfamily of our dataset, and then map functional sites from each domain in the superfamily onto the representative.
Specifically we used this approach to map functional p53 REs in the proximity of all annotated coding genes, searched for high affinity p53 REs in the entire genome, and mapped functional p53 REs within ENCODE-defined distant enhancer regions.
A dense and accurate consensus map specific for T. durum will greatly facilitate genetic mapping, functional genomics and marker-assisted improvement.
We validated all the obtained hits by mapping functional domains and active site residues, yet the possibility of obtaining false positives cannot be ignored.
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