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It treats the sequence of pairs of known haplotypes as hidden states and models the sequence of hidden state change along the sequence with switching rates depending upon a recombination map estimated from the reference data.
The locations of recombination hotspots and coldspots were obtained from a fine-scale genetic map estimated from patterns of genetic variation, which provides a kilobase-scale resolution of recombination rates [ 34, 35].
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Figure 20 shows the true permeability, the initial guess, and the permeability maps estimated from the three fractions.
To formally address the differences between analyses with scaled- and unscaled-BOLD signal, we constructed an additional second-level GLM analysis with activation maps estimated from the difference between scaled- and unscaled-BOLD maps.
Estimated from the genetic map estimated in this population and the physical map from the NCBI database.
Inferring Gene Modules with MixDTrees We estimate MixDTrees with MAP estimates from the Lymphoid data following the protocol in Section 3.1.
The data set contains 10 variable sites and 6 informative sites under the Clustal W alignment, 12 variable and 7 informative sites under the Muscle alignment, and 11 variable and 6 informative sites under the MAP estimate from the joint model (Table 1, – Indel contribution).
The first map was estimated from microsatellite markers in 146 Icelandic families; it has a resolution of ∼1 Mb and was used in many previous studies.
A map was estimated from the genotype data at 377 loci using Joinmap 3.0 [ 37], using a minimum LOD score of 6.0 to identify potential linkage groups.
Marker order for the linkage map was estimated from recombination frequencies observed in the entire population of 160 RILs, i.e., from the most complete dataset, in earlier experiments [ 48].
An approximation of the energy distribution of an image (E-map) is estimated from highly undersampled k-space data acquired in a prescan and efficiently recycled in the main scan.
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