All stimulations were accompanied by recordings of SPI, ANI, PRD, HR, mean arterial pressure (MAP) and BIS.
Results Under propofol sedation, sensitivity and specificity of ANI (AUC = 0.97 and 0.99), SPI (AUC = 0.86 and 0.90) and PRD (AUC = 1.00 and 0.96) for detecting both painful stimuli were high compared to HR, MAP and BIS (AUC = 0.75 and 0.74, 0.74 and 0.76 and 0.53 and 0.58, resp., Fig. 67a + b).
Likewise, with propofol sedation and remifentanil 0.2 mcg/kg/min, sensitivity and specificity of ANI (AUC = 0.82 and 0.80)., SPI (AUC = 0.73 and 0.84) and PRD (AUC = 0.63 and 0.68) for detecting both painful stimuli were higher compared to HR, MAP and BIS (AUC = 0.52 and 0.51, 0.48 and 0.48 and 0.52 and 0.60, resp., Fig. 67c-f).
HR, MAP, and BIS values in groups E1 5 were within the normal range at the different times and doses (P > 0.05).
Serum cortisol, aldosterone, adrenaline, and noradrenaline levels were measured, and HR, MAP, and BIS values recorded, before intubation (T0), and at 1 h, 2 h, and 3 h after intubation (T1 3).
The plasma adrenaline and noradrenaline levels, HR, MAP, and BIS in groups E1 5 were within the normal range at the different times and with the different doses (P > 0.05).
MAP and Bi-PAP-A have the potential to screen for a cocktail of mutations in large populations for which early embryonic mutations (mosaicism) as well as germline mutations could be detected.
We conclude that MAP, PAP and Bi-PAP-A may utilize this resource to facilitate cost-effective preventive medicine, e.g., see below.
The map of Te and Bi element indicated the distribution of both Te and Bi is homogeneous and locates the same sites, which is favorable to Te Bi binary system.
The BI MAP and best ML trees were not significantly different from one another as judged by ML methods via GARLI and CONSEL (Table 2).
The BI MAP and best ML tree (Additional file 1: Figure S1) were largely congruent (also see Additional file 1: Figure S2, Additional file 1: Figure S3 for BI consensus and ML bootstrap trees, respectively).
