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Basically there have been two approaches for numerical characterization, both of which use the graphical representation to map a DNA sequence into a set of numbers.
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In [ 1], we introduced a method that maps a DNA sequence onto a point within the regular tetrahedron (RT).
The region responsible for increased transcription of the Usf1 gene in BALB/cJ mice has been mapped to a DNA fragment containing about 1000 base pairs.
We found that the relative number of reads mapping to a DNA block depended on the molecular biology protocol used, thus necessitating use of a empirical normalization rather than simply a measure such as GC content.
However, gene silencing always maps to a DNA polymorphic cyc308G allele with a single nucleotide polymorphism in an unmethylated region 308 nt downstream of the stop codon and never to the more common wild type CYC308A allele.
The transcription profile of genes whose expression is modulated by iron levels was mapped by a DNA microarray analysis, and revealed 155 genes which were iron-regulated; one third of these were regulated by IdeR [ 94].
The inter-nucleotide distance mapping characterizes completely a DNA sequence, in the sense of providing a invertible mapping: the original sequence can be reconstructed from the inter-nucleotide distances.
In a given day, he will hear a replay of McGwire's 70th home run on KMOX radio, then will conduct research to help build a DNA map.
A map of DNA methylation at single-base resolution is referred to as methylome or epigenome.
DNA gel blot analysis was used to construct a DNA methylation map comparing P1-mm and P1-wr [W23] (Figure 4A).
A typical Hi-C experiment yields a DNA contact map, that is, a matrix indicating the frequency of interactions between all pairs of loci at a given resolution.
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