While many diseases are well described by this model, some--like many cancers are not.
While the primary genetic insult in DMD is well described, many details of the molecular and cellular pathologies that follow dystrophin loss are incompletely understood.
Though the protein domain structure is well described, many fundamental aspects of EBNA1 biology remain poorly understood.
Many prognostic factors are well described, but socio-economic factors and screening mammography have produced contradictory results (Klemi et al, 2003; Gill et al, 2004; Joensuu et al, 2004).
This topic is well described in many books on FEM for structural mechanics, see e.g. [16, 17].
Site-scale species richness (alpha diversity) patterns are well described for many present-day ecosystems, but they are difficult to reconstruct from the fossil record.
Global loss of methylation is well described for many solid tumors and also for hepatocellular carcinoma [21].
In the last few years, it has been increasingly realized that there are many situations which are not well described by well-mixed (mean-field) models, lattices and uniformly distributed spatial models.
However, this estimate requires cautious interpretation and it is likely that many morphospecies, more or less well described, will include a number of cryptic or pseudocryptic variants [e.g., [125]].
