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Many vitro models are developed to study the mechanism of angiogenesis, making a great deal of contribution to drug development against tumor, and often may be expensive, time-consuming.
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However, many publications continue to report the utilization of inappropriate methods of qPCR normalization, and for many in vitro models, no consistent set of empirically tested normalization controls have been identified.
However, many in vitro models fail to accurately reflect the level of protection afforded to the most resistant subset of leukemic cells during coculture with BMM elements.
26 Besides animal models, many in vitro models have widely shown the protective effects of SIRT1.
In addition, many in vitro models have been used to study microenvironmental mediators of cell phenotype and matrix synthesis.
Fibrin's critical role in the wound healing process has led to its use in many in vitro models to examine fibroblast function in healing.
Injury induced OA is a disorder affecting multiple organs of the synovial joint, yet many in vitro models to study injury induced OA only examine the cartilage.
While many in vitro modeling approaches exist, these simply cannot substitute for data obtained from appropriate animal models.
Many different in vitro models have been developed to study the translocation of nanoparticles.
To date, RNAi approaches have been used to efficiently silence the COX-2 protein in many different in vitro models (for a review, see Strillacci et al, 2010).
Under the high glucose burden imposed by diabetes, cutaneous and extra cutaneous fibroblasts appear perturbed; and for many years, in vitro models recreating "clinical hyperglycemia" have proved to disrupt normal fibroblasts physiology and derange the secretion of extracellular matrix ingredients.
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