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Diabetes mellitus is associated with endothelial dysfunction that is believed to result in impaired release of vasoconstrictor and vasodilator substances from the endothelium and thereby diminished reactivity of many vascular beds.
Fenestrae in many vascular beds are spanned by a diaphragm formed from the protein PV1.
Proper endothelial function is of crucial importance in regulation in many vascular beds [ 10].
Because noradrenaline induces vasoconstriction in many vascular beds (visibly in the skin), however, it may decrease renal and visceral blood flow, impairing visceral organ function.
It is well known that intravenous administration of L-arginine causes vasodilatation and augmented blood flow in many vascular beds [ 19– 219.
Similar(55)
Third, the microvascular abnormalities present in the retina may also be occurring in many other vascular beds, and CV outcomes may be due in part to accumulated microvascular abnormalities in the myocardial microcirculation, arterial wall (i.e., vasa vasorum), and elsewhere.
Again this is too slow to account for the acute increase, but may be responsible for the high hydraulic conductivity maintained in many fenestrated vascular beds in which VEGF is constitutively produced (e.g. salivary gland, adrenal gland, ovary, pituitary, etc).
Vascular beds of many organs and tissue, cancer, immune and stem cells are among the key targets.
In ECs CCE has been reported for several different vascular beds [51,55,56], although as with many other cell types, recording of their inward current (ICRAC) are scarce, due presumably to its small size.
So, while HUVECs are not microvascular cells, they do share many of the important characteristics exhibited by such cells isolated from numerous vascular beds.
There would be some rationale for evaluating ET receptor antagonism in this patient population, because there are many histopathological similarities between the arterial disease of SSc in the pulmonary, digital and renal vascular beds.
Related(20)
multiple vascular beds
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many vascular biologists
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