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Mature miRNAs have many variants with different length, named isomiR.
This implicitly disregards many variants with functional effects that are not associated with disease.
Many variants with small effects may contribute to fracture risk, but only a few vitamin D-related genetic polymorphisms have been reported to be associated with fracture risk [ 33].
The observation that associations are present only when less stringent p-value thresholds are used implies that there are many variants with very weak effects on arsenic metabolism that also influence skin lesion risk.
There is also extraordinary variability in the patterns of sex chromosomes: not only the XY system dominating in mammals and the ZW system in lepidoptera and birds but also many variants with multiple X or Y chromosomes found in both animals and plants with the extreme example of five Xs and five Ys in the male platypus (McMillan et al. 2007; Ming et al. 2011).
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Many variants associated with complex traits and diseases have been discovered so far through the GWAS approach.
Facilitated by technological developments in molecular biology, genetic epidemiologists have so far discovered many variants associated with several common diseases and traits such as Type 2 Diabetes, age-related macular degeneration and Crohn's disease [ 1].
Each variant should also be given a phenotypic score, which in most cases will be 'classic or most severe' associated with homozygous or hemizygous loss-of-function variants or with well-characterized missense variants (e.g., sickle cell), but many variants are associated with milder phenotypes which must be explained when known.
The song is a slow whistled pee-pee-pee with many variants, including a faster version, and may be intermingled with the call.
Membrane systems are presented together with many variants and examples in [10].
It traditionally emphasizes combining information from good parents (crossover) with many variants, e.g., reproduction models, operators.
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