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These common variations represent the lower boundary of variation events in A. gambiae because the intersection of two sets also removed many true positive TSVs.
However, many true positive results will be eliminated in exchange.
So if using the above criterion, many true positive sites might be missed.
When β is large, many correct contigs are removed and many true positive transcripts cannot be assembled.
CS-BLAST can detect many true positive relations from the confined superfamily group, rather than from various superfamilies, as shown in the Venn diagrams (Fig. 4).
The inclusion of more false positives, which arise from the null distribution, would not change the underlying correlations; however, if too many true positive signals were missing, it would lead to substantial reduction of the test power.
Similar(53)
Many true positives are missed.
These results should be viewed as an extreme case for our validation process, since too many true positives were wrongly filtered out from the final result.
Possibly, the widespread problem of protein misfolding and aggregation leads to many true positives being skipped.
Any lower threshold significantly increases the number of reported variants that are likely false positives, without adding many true positives (see below).
Re-annotation experiments would necessitate a higher threshold to avoid false positives, but experiments looking for novel junctions could use a lower threshold to include as many true positives as possible.
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