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15 However, most of the studies included in this meta-analysis were small (<100 patients); were dated, with <span class="lh">many trials published in the 1980s; and often did not distinguish between regional and combined general and regional anesthesia.
As many trials published or planned at the beginning of 1990s, we pooled together patients with colon and rectal cancer (Panettiere et al, 1988; Laurie et al, 1989; Quasar Collaborative Group, 2000; Taal et al, 2001) and stage II or III disease (Laurie et al, 1989; Moertel et al, 1990; Wolmark et al 1993, 1999; Quasar Collaborative roup, 2000; Di Costanzo et al, 2003; Andrè et al, 2004).
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Oncology is one of the most funded fields of medicine, and there are many large trials published.
For each clinical trial, the investigators asked how many of the other trials, published before it on the same topic and included with it in the meta-analysis, were cited.
The trials included in the review spanned nearly thirty years and it was noticeable that the more recent trials reported necessary information more clearly and comprehensively than trials published many years previously.
However, the publication of the REDOXS trial necessitates a close examination of the many new GLN supplementation trials published recently to examine if there has been a change in the fundamental signal of benefit of GLN supplementation of PN seen in historical trials in the recent era of critical care practice.
As many trials now publish a protocol, providing additional intervention detail in the published protocol may be one way of overcoming word limit restrictions in the trial's primary paper.
In a study of randomised controlled trials published in leading medical journals many of the diseases afflicting the south are understudied [ 14].
Sadly the evidence is overwhelming and irrefutable that many trials are never published and that there is a systematic bias towards positive results.
Yet, the ICMJE editors who publicly declared their intent to publish only advance-registered trials nevertheless published many trials that had not been advance-registered.
Unfortunately, many trials continue to be published that have not been registered and, as Goldacre points out, most drugs in use today were launched long before registers of trials were introduced.
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