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Many transcripts exhibited altered mRNA half-lives in human OA chondrocytes compared to normal cells.
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Alterations in transcript abundance were highly dynamic, with many transcripts exhibiting large fold-changes and the largest changes occur very early in the time-course.
However in studies where taxonomic divergence between groups has been taken into account, many transcripts exhibit changes in expression levels beyond what would be expected under genetic drift alone.
In our study, many ABA-responsive transcripts exhibited different expression levels between the hybrid and its parents.
Many of these transcripts exhibit a stable secondary structure and are thus strong candidates for primate-specific non-coding RNAs.
We observed that the known transcripts exhibited an expected distribution of transcript length as previously described32 with an abundance of transcripts having length between ~102 bp and ~104 bp.
Over 10,000 transcripts exhibited large-scale expression pattern differences during in vitro and in vivo maturation.
The accumulation level of LOX4 transcripts exhibited a biphasic pattern.
Both LOX4 and PP2A3&4 transcripts exhibited a biphasic accumulation pattern.
The dose response relationship for the expression level of the 130 shared transcripts exhibited different patterns (Figure 3).
The remaining transcripts exhibited partial ORFs.
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