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However, increasing evidence indicates that leptin is produced in many tissues other than adipocytes, and that enhanced leptin levels are associated with the advent of reproductive maturity and fertility [7], [8], including gonad maturation and embryonic development [9].
Here, genes that were upregulated in the embryonic liver were classified as related to metabolism and transport, indicating that the embryonic liver expresses multiple metabolic genes already at this early developmental stage, while genes that were downregulated in the embryonic liver were classified as related to development of many tissues other than the liver.
As GLP-1Rs are abundant in many tissues other than the pancreas, their activation is associated with a broad variety of extrapancreatic effects, some contributing to the glucoregulatory actions.
Among these active transcription factors, although E2F1, AP2, Sp1 and CREB exist ubiquitously in many tissues, other transcription factors, ZF5, HIF1, AhR and Egr3 were found to specifically exist in SH-SY5Y neuroblastoma cells [ 26].
As ABCG2 is widely expressed in many tissues other than the renal tubule [ 4], it seems likely that the effects of ABCG2 genetic variation on hyperuricemia and gout risk act on other sites of urate metabolism or clearance, most likely gastrointestinal [ 8].
Similar(55)
CYP genes show varying degrees of tissue selective expression with some expressing widely in many tissues, whereas others showing stringent tissue specificity.
Many systemically administered chemotherapeutic agents exert their effects non-specifically on many rapidly dividing tissues other than the cancer itself.
Recently, a study extended these findings to identify chimerism in many tissues, including somatic tissues from other lineages and germ cells.
Many other tissues store lead, but those with the highest concentrations (other than blood, bone, and teeth) are the brain, spleen, kidneys, liver, and lungs.
Many other tissues can be indirectly affected or need coordinate regulation by estrogenic actions because they are involved in supporting downstream reproductive functions.
DGAT2 is expressed in adipose tissue, liver and many other tissues, including cardiac muscle, small intestine, skeletal muscle, and kidney [2].
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